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(Junior) Scientist, Nonclinical Development

Job

Position
We are seeking a highly skilled, innovative and motivated (junior) scientist with a desire to generate innovative new medicines for patients to join our team. He/she will be responsible for the discovery and development of new AAV-based vectors targeting cardiovascular diseases. Within nonclinical development, target safety assessment, lead optimization, and pharmacology experiments are executed both in vitro and in vivo. In addition to assay development and fit for purpose mechanistic studies, the scientist will explore new therapeutic modalities in cardiovascular disease based on hypothesis-driven research. The scientist will closely work together with our Vector Development team. The aim of these projects is to develop new product candidates for clinical testing.
The scientist will be responsible to apply and help develop nonclinical assays for development of AAV-based vectors for cardiovascular diseases. The scientist will be required to present results and updates at project team meetings, and maintain accurate and well-organized experiment records. He/she will have a unique opportunity to participate in multidisciplinary projects with colleagues from MeiraGTx Amsterdam, London and New York. He/she is reporting to the Sr Director Nonclinical Development.

Key Responsibilities:

The scientist is responsible for establishing state of the art model systems and develop protocols for nonclinical testing in cardiomyocyte cells, including in vitro models (e.g. iPSC) and in vivo using relevant disease models. He/she will act as our subject matter expert when it comes to cardiovascular disease.

Profile

Minimum Qualifications:
• PhD in Cardiovascular diseases, and 2 years’ experience in cardiovascular/electrophysiology research, preferably in a biopharmaceutical company
• Expertise in cardiac biology and relevant in vivo models
• Hands-on experience in culturing primary cardiomyocytes, as well as generation and culturing of human iPSC derived cardiomyocytes
• Demonstrated experience with electrophysiology methods such as MEA, patch-clamp
• Hands-on experience in conducting animal experiments
• Accurate, pro-active and well-organized
• Good documentation skills, writing and reviewing SOPs, study protocols and study reports
• Flexible, positive, and professional attitude
• Proficient in English

Preferred skills:

• Knowledge of cell line development using CRISPR/Cas9 gene editing technology
• Experience with ex vivo analysis, such as (RT-)qPCR, histology of tissue sections, including immunofluorescence, FISH, and/or IHC is a plus
• Experience in management of contract research organizations and academic partners
• Gene therapy experience and know-how
• Experience working in a gene therapy company with similar responsibilities is a plus
• Ability to communicate clearly and concisely, both verbally and in writing
• Ability to thrive in a demanding, fast-paced environment

Benefits

MeiraGTx Netherlands offers the opportunity to work in an exciting and entrepreneurial environment. We allow you to grow within an organization that encourages talent, and that supports the development of its employees and fuels excellence. We are project focused and have built a culture with a high degree of personal empowerment. Our energetic and enthusiastic employees participate in and influence the long-term growth of MeiraGTx.

Company profile

MeiraGTx Netherlands B.V. is an Amsterdam based biopharmaceutical company developing local gene therapy for different indications. The company specializes in the development of viral gene therapy vectors, in particular adeno-associated virus (AAV) based therapeutics. Our goal is to develop potentially curative treatments for patients living with serious diseases. Several product candidates are in the discovery and development phase. MeiraGTx Netherlands B.V. is a wholly-owned subsidiary of MeiraGTx Holdings plc. With sites in New York, London, Shannon and Amsterdam, our global footprint provides us the opportunity to partner with leading institutions around the world, allowing us to deepen our understanding of diseases and their progression.

Contact

To apply, please send your full resume and motivation by e-mail to Anouk Veneboer, manager operations, e-mail: Anouk.Veneboer@meiragtx.com / Address: Paalbergweg 2, 1105 AG Amsterdam, The Netherlands. For questions related to the position, please contact Marleen van Loenen (Sr Director Nonclinical Development: leen.vanloenen@meiragtx.com">Marleen.vanloenen@meiragtx.com).

(Junior) Scientist, Nonclinical Development

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