Translational Research Lead (R6658)

Job

At Genmab, we’re committed to building extra[not]ordinary futures together, by developing antibody products and pioneering, knock-your-socks-off therapies that change the lives of patients and the future of cancer treatment and serious diseases. From our people who are caring, candid, and impact-driven to our business, which is innovative and rooted in science, we believe that being proudly unique, determined to be our best, and authentic is essential to fulfilling our purpose.

The Role

As Translational Research Lead, you will work in a global multidisciplinary project team to develop one or more novel therapeutic antibody compounds designed to treat cancer. You will be a member of the Translational Research (TR) team, which is embedded in the larger Translational Research & Precision Medicine department (TR&PrM). As TR Lead you are responsible for the design and execution of the TR&PrM strategy for projects in preclinical and early clinical development. As TR Lead you report to the Director Translational Research, who is responsible for strategical oversight across multiple (pre)clinical development programs within TR. You will work closely together with scientists and research associates in your project team.

Responsibilities

• Design, oversight, and execution of the preclinical strategy to support first-in-human trial design and application, patent applications and ongoing clinical development (e.g., functional characterization of our antibody therapeutics in preclinical experiments, indication prioritization, pharmacology studies supporting pharmacokinetic modeling, preclinical biomarker identification).

• Providing clear instructions and guidance to one or more research associates and/or scientists within the TR team who are responsible for preclinical laboratory research.

• Design, oversight, and execution of biomarker strategy for the first-in-human trial, biomarker assay identification and interpretation clinical biomarker data.

• Establishing and maintaining collaborative relationships with internal and external (academic or CRO) functional experts that can contribute to the TR strategy.

• Representing TR&PrM in the compound development team (CDT), a multidisciplinary project team tasked with progressing novel antibody molecules through (pre)clinical development

• Chairing the program-specific TR Team, which is a CDT sub team composed of multidisciplinary experts all contributing to execution of the translational strategy.

• Contributing to regulatory documentation and health authority interactions, ultimately leading to ultimately leading to the application for the first-in-human trial (IND/CTA submission), approval and preparation for clinical development, e.g., providing the translational/biomarker sections in clinical protocols and clinical study reports.

• Regular reporting of TR/Biomarker data to the TR&PrM leadership team and Genmab senior management.

Requirements

• A Ph.D. or an M.D./Ph.D. in immune-oncology, oncology, immunology, or related field, with at least eight or more years’ experience of translational research, applicable biomarker, program management and/or clinical trial. 

• Pharmaceutical or biotechnology industry research experience, including experience (translational research) in clinical development is preferred.

• Experience in the supervision of research associates and scientists.

• A solid background in (immune)oncology supported by a strong publication record.

• You strive for scientific excellence.

• You demonstrate excellent project managements skills.

• You work well in a matrix organization; you like to work with a team of experts to get things done.

• You can work and like to work in global project teams.

• Strong communication skills.

• A ‘getting things done’ mentality, pro-active, enthusiastic and goal orientated.

• Excellent verbal and written communication skills in English.

• Travel will be approximately 10%.

About You

• You are passionate about our purpose and genuinely care about our mission to transform the lives of patients through innovative cancer treatment
• You bring rigor and excellence to all that you do. You are a fierce believer in our rooted-in-science approach to problem-solving
• You are a generous collaborator who can work in teams with diverse backgrounds
• You are determined to do and be your best and take pride in enabling the best work of others on the team
• You are not afraid to grapple with the unknown and be innovative
• You have experience working in a fast-growing, dynamic company (or a strong desire to)
• You work hard and are not afraid to have a little fun while you do so

Locations

Genmab leverages the effectiveness of an agile working environment, when possible, for the betterment of employee work-life balance. Our offices are designed as open, community-based spaces that work to connect employees while being immersed in our state-of-the-art laboratories. Whether you’re in one of our collaboratively designed office spaces or working remotely, we thrive on connecting with each other to innovate.

Company profile

About Genmab

Genmab is an international biotechnology company with a core purpose to improve the lives of people with cancer. For more than 20 years, Genmab’s vision to transform cancer treatment has driven its passionate, innovative and collaborative teams to invent next-generation antibody technology platforms and leverage translational research and data sciences, fueling multiple differentiated cancer treatments that make an impact on people’s lives. To develop and deliver novel therapies to patients, Genmab has formed 20+ strategic partnerships with biotechnology and pharmaceutical companies. Genmab’s proprietary pipeline includes bispecific T-cell engagers, next-generation immune checkpoint modulators, effector function enhanced antibodies and antibody-drug conjugates.

Genmab is headquartered in Copenhagen, Denmark with locations in Utrecht, the Netherlands, Princeton, New Jersey, U.S. and Tokyo, Japan. For more information, please visit Genmab.com and follow us on Twitter.com/Genmab.